Systemic inflammation and causal risk for Alzheimer's dementia: Possibilities and limitations of a Mendelian randomization approach
نویسندگان
چکیده
منابع مشابه
Mendelian randomization: prospects, potentials, and limitations.
Mendelian randomization is the term applied to the random assortment of alleles at the time of gamete formation. This results in population distributions of genetic variants that are generally independent of behavioural and environmental factors that typically confound epidemiological associations between putative risk factors and disease. In some circumstances this can provide a study design a...
متن کاملPromises and limitations of mendelian randomization for evaluation of biomarkers.
Mendelian randomization provides a theoretically powerful approach to account for unmeasured confounding variables in the evaluation of relationships of biomarkers with disease outcomes. First proposed by Katan as a way to distinguish whether low cholesterol concentrations were a cause of cancer or a consequence of carcinogenesis (1 ), the approach seeks to capitalize on the random assignment o...
متن کاملMendelian Randomization Causal Analysis Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
Background: Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods. Methods: The associations of BMI with cardiovascular outcomes [coronary heart disease (CHD), heart failure and ischaemic stroke], and associations o...
متن کاملMendelian randomization as an instrumental variable approach to causal inference.
In epidemiological research, the causal effect of a modifiable phenotype or exposure on a disease is often of public health interest. Randomized controlled trials to investigate this effect are not always possible and inferences based on observational data can be confounded. However, if we know of a gene closely linked to the phenotype without direct effect on the disease, it can often be reaso...
متن کاملInstrumental variable estimation of causal risk ratios and causal odds ratios in Mendelian randomization analyses.
In this paper, the authors describe different instrumental variable (IV) estimators of causal risk ratios and odds ratios with particular attention to methods that can handle continuously measured exposures. The authors present this discussion in the context of a Mendelian randomization analysis of the effect of body mass index (BMI; weight (kg)/height (m)(2)) on the risk of asthma at age 7 yea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Aging Medicine
سال: 2018
ISSN: 2475-0360
DOI: 10.1002/agm2.12046